甲狀腺疾病研究室

研究方向

1．BRAF、RAS等基因突變驅動(dòng)甲狀腺腫瘤惡變的新型分子機制；

2．碘難治性甲狀腺癌發(fā)生的分子機制及逆轉研究；

3．小分子化合物抑制甲狀腺癌生長(cháng)、轉移、失分化的藥理學(xué)研究；

4．腫瘤微環(huán)境與甲狀腺癌發(fā)生發(fā)展關(guān)系的研究；

5．其他臨床甲狀腺病變的病因、診斷及干預手段的研究；

6．核技術(shù)于碘難治性甲狀腺癌診治中的應用研究。

獎項、成果、課題等

國家自然科學(xué)基金項目5項

1. 張莉，國家自然科學(xué)青年基金，（81402214）轉錄因子MEF2A介導BRAF突變型甲狀腺乳頭狀癌發(fā)生發(fā)展的新機制，2015.1-2017.12 

2. 程獻，國家自然科學(xué)青年基金（81602352),表觀(guān)遺傳調節子MKL1介導轉錄復合物組裝促甲狀腺癌侵襲轉移的新機制，2017.1-2019.12 

3. 高巖巖，國家自然科學(xué)青年基金（81602353）,甲狀腺癌BRAF V600E在DRP1介導的線(xiàn)粒體穩態(tài)中的調控新機制研究，2017.1-2019.12 

4. 張莉，國家自然科學(xué)基金面上項目（81972503), 腫瘤炎性微環(huán)境BRAF-組胺/組胺受體正反饋環(huán)路促進(jìn)甲狀腺乳頭狀癌失分化的新機制, 2020.1-2023.12 

5. 徐石宸, 國家自然科學(xué)青年基金(82103656),BRAF突變驅動(dòng)硫化氫-胱硫醚γ裂解酶體系失調促進(jìn)甲狀腺癌細胞淋巴結轉移的機制研究, 2022.1.1-2024.12

江蘇省自然科學(xué)基金1項

高巖巖, 江蘇省自然科學(xué)基金面上項目(BK20171145), 線(xiàn)粒體定位BRAF V600E調控線(xiàn)粒體凋亡抵抗甲狀腺癌放射性碘治療敏感性的研究, 2017.7-2020.6

江蘇省衛健委項目 4項

1. 張莉 國家衛生部科研基金（W201304），姜黃素對甲狀腺癌放射性碘-131治療的增敏研究，2014.1.1-2016.12.31

2. 張莉，省衛計委面上項目（H2017032），基于炎癥因子早期預測甲狀腺癌分子靶向藥物療效的研究，2018.1-2019.12

3. 程獻，省健計委面上項目（M2021060），靶向BRG1/TERT復合物酶活促碘耐受甲狀腺癌放射敏感性的研究，2022.1-2024.12

4. 俞惠新，江蘇省衛生廳科技項目（H2010027），放療增敏劑在抗碘-131甲狀腺癌治療中的應用，2010.10～2013.9

無(wú)錫市科技局項目2項

1. 張莉, 無(wú)錫市科技局項目(Y20212051), 維生素C增強甲狀腺癌放射性碘-131治療敏感性的應用研究；2021.7-2024.6

2. 程獻, 無(wú)錫市科技局項目(Y20212052), BRG1介導TRET新酶活促甲狀腺癌碘抵抗的表觀(guān)調控機制研究, 2021.7-2024.6

無(wú)錫市衛健委項目3項

1. 徐石宸，無(wú)錫市衛健委科研項目（Q202103），硫化氫供體藥物靶向基質(zhì)金屬蛋白酶抑制甲狀腺癌轉移的實(shí)驗研究，2022.1-2023.12

2. 徐石宸,無(wú)錫市衛計委科研項目（Q201836），ZNF148多態(tài)性檢測用于甲狀腺結節良惡性鑒別的研究，2019.1-2020.12

3. 程獻，無(wú)錫市衛計委青年項目（Q201608）MEF2A評估甲狀腺癌復發(fā)轉移風(fēng)險的研究，2017.1～2018.12

代表性論文

近5年發(fā)表的甲狀腺疾病研究相關(guān)的代表性論文：

1)Cheng, X. et al. Risk-stratified Distant Metastatic Thyroid Cancer with Clinicopathological Factors and BRAF / TERT Promoter Mutations. Experimental and Clinical Endocrinology & Diabetes, 

doi:10.1055/a-2177-1051 (2023).

全文鏈接：/upload/autofile/20240307/202403077211.jpg  

2)Zhang, L. et al. Curcumin induces mitophagy by promoting mitochondrial succinate dehydrogenase activity and sensitizes human papillary thyroid carcinoma BCPAP cells to radioiodine treatment. 

Toxicology in Vitro 93, doi:10.1016/j.tiv.2023.105669 (2023).

全文鏈接：/upload/autofile/20240307/202403076583.jpg

3)Xu, S. et al. Inactivated SARS-CoV-2 vaccination does not disturb the clinical course of Graves' disease: An observational cohort study. Vaccine 41, 5648-5654, doi:10.1016/j.vaccine.

2023.07.053 (2023).

全文鏈接：/upload/autofile/20240307/202403078781.jpg

4)Xu, S., Cai, G., Zhu, Y. et al. A Combination of BRAF and EZH1/SPOP/ZNF148 Three-Gene Mutational Classifier Improves Benign Call Rate in Indeterminate Thyroid Nodules. Endocr Pathol 34, 

323–332 (2023).

全文鏈接：/upload/autofile/20240307/202403072552.jpg  

5)Zhang, L. et al. Inflammatory tumor microenvironment of thyroid cancer promotes cellular dedifferentiation and silencing of iodide-handling genes expression. Pathology Research and Practice 

246, doi:10.1016/j.prp.2023.154495 (2023).

全文鏈接：/upload/autofile/20240307/202403072336.jpg

6)Wang, Y. et al. Diallyl trisulfide inhibits the metastasis of anaplastic thyroid carcinoma cells by targeting TGF-?-Smad3-integrin?2?1 signaling pathway. Process Biochemistry 124, 71-80, 

doi:10.1016/j.procbio.2022.11.009 (2023).

全文鏈接：/upload/autofile/20240307/202403071493.jpg

7)X. Cheng, S. Xu, Y. Zhu, et al., Markedly elevated serum preoperative thyroglobulin predicts radioiodine-refractory thyroid cancer, Eur. J. Clin. Invest. 2022, 52, e13721.

8)L. Wu, S. Xu, X. Cheng, et al., Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy-lysosome mediated OCT4A degradation, Phytotherapy Research. 

2022, 36, 938-950. 

全文鏈接：/upload/autofile/20240307/202403074663.jpg

9)L. Zhang, S. Xu, X. Cheng, et al., Curcumin induces autophagic cell death in human thyroid cancer cells, Toxicol. In Vitro 2022, 78, 105254.

全文鏈接：/upload/autofile/20240307/202403075104.jpg

10)S. Xu, X. Cheng, J. Wu, et al., Capsaicin restores sodium iodine symporter-mediated radioiodine uptake through bypassing canonical TSH-TSHR pathway in anaplastic thyroid carcinoma cells, 

Journal of Molecular Cell Biology. 2022, 13, 791-807.

全文鏈接：/upload/autofile/20240307/202403075733.jpg

11)L. Zhang, S. Xu, X. Cheng, et al., Curcumin enhances the membrane trafficking of the sodium iodide symporter and augments radioiodine uptake in dedifferentiated thyroid cancer cells via 

suppression of the PI3K-AKT signaling pathway, Food Function 2021, 12, 8260-8273.

全文鏈接：/upload/autofile/20240307/202403077853.jpg

12)L. Zhang, S. Xu, X. Cheng, et al., Diallyl trisulphide, a H2S donor, compromises the stem cell phenotype and restores thyroid-specific gene expression in anaplastic thyroid carcinoma cells 

by targeting AKT-SOX2 axis, Phytotherapy Research. 2021, 35, 3428-3443. 

全文鏈接：/upload/autofile/20240307/202403072241.jpg

13)X. Wang, S. Xu, L. Zhang, et al., Vitamin C induces ferroptosis in anaplastic thyroid cancer cells by ferritinophagy activation, Biochem. Biophys. Res. Commun. 2021, 551, 46-53.

全文鏈接：/upload/autofile/20240307/202403073154.jpg

14)S. Xu, X. Cheng, L. Wu, et al., Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload, Cellular 

Signaling. 2020, 75, 109733.

全文鏈接：/upload/autofile/20240307/202403076794.jpg

15)Xu S, Pan J, Cheng X, Zheng J, Wang X, Guan H, et al. Diallyl trisulfide, a H2S donor, inhibits cell growth of human papillary thyroid carcinoma KTC-1 cells through a positive feedback loop 

between H2S and cystathionine-gamma-lyase. Phytotherapy Research. 2020.

全文鏈接：/upload/autofile/20240307/202403073222.jpg

16)Zheng J, Cheng X, Xu S, Zhang L, Pan J, Yu H, et al. Diallyl trisulfide induces G2/M cell-cycle arrest and apoptosis in anaplastic thyroid carcinoma 8505C cells. Food Function. 2019;10(11):

7253-61.

全文鏈接：/upload/autofile/20240307/202403074175.jpg

17)Cheng X, Xu S, Pan J, Zheng J, Wang X, Yu H, et al. MKL1 overexpression predicts poor prognosis in patients with papillary thyroid cancer and promotes nodal metastasis. Journal of Cell 

Science. 2019;132(16).

全文鏈接：/upload/autofile/20240307/202403077061.jpg

18)Gao Y, Yang F, Yang X, Zhang L, Yu H, Cheng X, Xu S, Pan J, Wang K, Li P. Mitochondrial metabolism is inhibited by the HIF1α-MYC-PGC-1β axis in BRAF V600E thyroid cancer. The FEBS Journal.

2019;286: 1420-36.

全文鏈接：/upload/autofile/20240307/202403077188.jpg

19)Cheng X.#, Yao X.#, Xu S., Pan J., Yu H., Bao J., Guan H., Lu R., Zhang L.*. Punicalagin induces senescent growth arrest in human papillary thyroid carcinoma BCPAP cells via NF-kappaB 

signaling pathway. Biomedicine & pharmacotherapy. 2018; 103, 490-498.

全文鏈接：/upload/autofile/20240307/202403075913.jpg

20)Zhang L., Cheng X., Xu S., Bao J., and Yu H. Curcumin induces endoplasmic reticulum stress-associated apoptosis in human papillary thyroid carcinoma BCPAP cells via disruption of 

intracellular calcium homeostasis. Medicine (Baltimore). 2018; 97, e11095.

全文鏈接：/upload/autofile/20240307/202403076040.jpg

21)Xu S., Zhang L., Cheng X., Yu H., Bao J., and Lu R. Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel. Food & 

Function. 2018; 9, 344-354. 

全文鏈接：/upload/autofile/20240307/202403072106.jpg

22)Pan, J., Zhang, L., Xu, S., Cheng, X., Yu, H., Bao, J., and Lu, R. Induction of Apoptosis in Human Papillary-Thyroid-Carcinoma BCPAP Cells by Diallyl Trisulfide through Activation of the 

MAPK Signaling Pathway. Journal of Agricultural and Food Chemistry. 2018; 66, 5871-5878.

全文鏈接：/upload/autofile/20240307/202403072734.jpg

發(fā)明專(zhuān)利

一種癌癥聯(lián)合診斷標記物及其用途，ZL201710623889.2

團隊合影